## Abstract The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rat
✦ LIBER ✦
Induction of rat liver microsomal cytochrome P-450 isozymes and epoxide hydrolase by a series of 4′-substituted-2,3,4,5-tetrachlorobiphenyls
✍ Scribed by A. Parkinson; P.E. Thomas; D.E. Ryan; W. Levin; T. Fujita; S. Safe
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 705 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0300-483X
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In the early stage of drug discovery, thousands of new chemical entities (NCEs) may be screened before a single drug candidate can be identified for development. In order to accelerate the drug discovery process, we have developed higher-throughput enzyme assays to evaluate the inhibition of cytochr