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Metabolism of 2,3′,4′,5-tetrachlorobiphenyl by cytochrome P450 from rats, guinea pigs and hamsters

✍ Scribed by Nobuyuki Koga; Naoko Kikuichi; Tomoyo Kanamaru; Hiroaki Kuroki; Kimihiko Matsusue; Chuzo Ishida; Noritaka Ariyoshi; Kazuta Oguri; Hidetoshi Yoshimura


Book ID
117251266
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
570 KB
Volume
37
Category
Article
ISSN
0045-6535

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## Abstract The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rat