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Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

✍ Scribed by Carsten B Schmidt-Weber; Kurt Blaser

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
168 KB
Volume
16
Category
Article
ISSN
0952-7915

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✦ Synopsis

Transforming growth factor-b (TGF-b) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-b in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-b in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-b; however, TGF-b-mediated tissue remodelling can be a serious complication in such diseases.

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