𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Role of active and latent transforming growth factor β in bone formation

✍ Scribed by L. F. Bonewald; S. L. Dallas

Publisher
John Wiley and Sons
Year
1994
Tongue
English
Weight
864 KB
Volume
55
Category
Article
ISSN
0730-2312

No coin nor oath required. For personal study only.

✦ Synopsis

At first reading the statement "TCFP stimulates bone formation but inhibits mineralization" may appear to be an oxymoron. However, the bone formation process can take weeks to months to complete, and the unique properties of TGFP allow this factor to be stored in bone matrix in a latent form, ready to be activated and inactivated at key, pivotal stages in this long process. TGFp may act to trigger the cascade of events that ultimately leads to new bone formation. However, once this process is initiated, TGFp must then be inactivated or removed because if present in the later stages of bone formation, mineralization will be inhibited. The unique properties of TGFp and its role in bone remodeling are the subject of this review.

📜 SIMILAR VOLUMES

Cell-associated activation of latent tra
Cell-associated activation of latent transforming growth factor-β by calpain
✍ Mayumi Abe; Nobuyuki Oda; Yasufumi Sato 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB

Transforming growth factor-b (TGF-b) is normally secreted in a latent form, and plasmin-mediated proteolytic cleavage of latency-associated peptide (LAP), a component of latent TGF-b complex that makes the complex inactive, activates latent TGF-b. In the present study, we investigated the possible i

Immunocytochemical localization of laten
Immunocytochemical localization of latent transforming growth factor-β1 activation by stimulated macrophages
✍ Hyonkyong Chong; Yoram Vodovotz; George W. Cox; M.H. Barcellos-Hoff 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 773 KB

Transforming growth factor-beta1 (TGF-beta) is secreted in a latent form consisting of mature TGF-beta noncovalently associated with its amino-terminal propeptide, which is called latency associated peptide (LAP). Biological activity depends upon the release of TGF-beta from the latent complex follo

Active transforming growth factor-β in h
Active transforming growth factor-β in human melanoma cell lines: No evidence for plasmin-related activation of latent TGF-β
✍ Jozef Bizik; Diana Felnerova; Marta Grofova; Antti Vaheri 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 929 KB

Cultured human melanoma cells were found to secrete TGF-P mostly in latent biologically inactive form but in addition five of six melanoma cell lines studied produced in conditioned culture medium active TGF-p in the range from 370 to 61 0 pg per 1 O6 cells per 24 h. A distinct characteristic of the

Subcellular localization of (latent) tra
Subcellular localization of (latent) transforming growth factor β and the latent TGF-β binding protein in rat hepatocytes and hepatic stellate cells
✍ Sylke Roth-Eichhorn; Kitty Kühl; Axel M. Gressner 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 754 KB

Recently, the existence of the large latent transforming growth factor ␤ (TGF-␤) complex, consisting of TGF-␤, the N-terminal part of its precursor (latency-associated peptide [LAP]), and the latent TGF-␤ binding protein (LTBP), was demonstrated in rat liver parenchymal cells (PC) and stellate cells