𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Transforming growth factor type β regulation of actin mRNA

✍ Scribed by Edward B. Leof; Jacqueline A. Proper; Michael J. Getz; Harold L. Moses

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
705 KB
Volume
127
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Stimulation of quiescent cultures of AKR-2B cells with transforming growth factor type P (TGFP) resulted in a transitory increase in actin cytoplasmic poly(A) + RNA. Levels of actin rnRNA peaked approximately 4-8 hours subsequent to TGFP addition and approached basal levels by 24 hours. The accumulation of actin transcripts was dose dependent and insensitive to inhibitors of protein synthesis; 1-3 nglml TGFP induced maximal actin gene expression. Actin isotype-specific probes demonstrated that both @-and y-cytoplasmic actins are induced by TGFP.

📜 SIMILAR VOLUMES

Transforming growth factor β regulation
Transforming growth factor β regulation of cell proliferation
✍ Harold L. Moses; Robert J. Coffey Jr.; Edward B. Leof; Russette M. Lyons; Jorma 📂 Article 📅 1987 🏛 John Wiley and Sons 🌐 English ⚖ 606 KB

JORMA KESKI-OJA Two types of transforming growth factors (TGF) have been purified and well characterized, TGFa and TGFP. TGFa is a 5.6 kD single chain molecule that shows sequence homology to epidermal growth factor (EGF), binds to the EGF receptor, and has biological effects very similar to those o

Regulation of transforming growth factor
Regulation of transforming growth factor-β production by interleukin-12
✍ Thomas Marth; Warren Strober; Robert A. Seder; Brian L. Kelsall 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 847 KB

## Regulation of transforming growth factor-p production by interleukin-= The induction of peripheral tolerance following oral antigen administration in several autoimmune disease and conventional animal models correlates with the production of transforming growth factor-fJ (TGF-p) and T helper ty

Down-regulation of protein and mRNA expr
Down-regulation of protein and mRNA expression for transforming growth factor-β (TGF-β1) type I and type II receptors in human prostate cancer
✍ Yanping Guo; Stephen C. Jacobs; Natasha Kyprianou 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 298 KB 👁 1 views

Transforming growth factor-b (TGF-b1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investi

Purification of transforming growth fact
Purification of transforming growth factor type e
✍ Pamela G. Parnell; John Wunderlich; Bobbie Carter; Jaroslava Halper 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 498 KB

Transforming growth factor type e (TGFe) is a heat-and acid-stable polypeptide with an apparent molecular weight of 22,000, which stimulates the proliferation of certain epithelial and mesenchymal cells in monolayer and soft agar. TGFe has been purified to homogeneity. Initial acid-ethanol extractio