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Regulating the stability of TGFβ receptors and Smads

✍ Scribed by Lönn, Peter; Morén, Anita; Raja, Erna; Dahl, Markus; Moustakas, Aristidis

Book ID
109846858
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
929 KB
Volume
19
Category
Article
ISSN
0007-0610

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TGFbeta inducible early gene (TIEG) is a novel Krüppel-like transcriptional repressor that was recently shown to increase the activity of the TGFbeta/Smad signal transduction pathway by relieving negative feedback through repression of the inhibitory Smad7. Interestingly, while Smad7 is required for