To identify putative sequences that direct cell type-specific expression and/or enhance proteolipid protein (PLP) gene expression, glial or nonglial cells were transfected with various PLP-luciferase constructs that collectively span the entire mouse PLP-specific DNA present in a transgene known to
Regulated gene expression of myelin proteins
โ Scribed by C. Goujet-Zalc; M. Monge; B. Zalc
- Book ID
- 119107811
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 72 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0165-5728
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The myelin proteolipid protein (Plp) gene is expressed in oligodendrocytes and encodes the most abundant protein (approximately 50%) present in mature myelin from the central nervous system (CNS). Plp gene activity is low to nonexistent early in development but sharply increases, concurrently with t
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