To identify putative sequences that direct cell type-specific expression and/or enhance proteolipid protein (PLP) gene expression, glial or nonglial cells were transfected with various PLP-luciferase constructs that collectively span the entire mouse PLP-specific DNA present in a transgene known to
Where, when and how much: regulation of myelin proteolipid protein gene expression
β Scribed by P.A. Wight; A. Dobretsova
- Book ID
- 105757725
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 223 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1420-682X
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## Abstract A Model culture system of C6 rat glioma cells was used to test the involvement of cAMP in the regulation of the myelin PLP and MAG genes. The treatment of cells with isoproterenol (10^β5^to 10^β8^M) upregulated the expression of the PLP and MAG genes in a concentrationβdependent manner.
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