Regression of Adjuvant-Induced Arthritis in Rats Following Bone Marrow Transplantation
โ Scribed by Dirk W. Van Bekkum, Els P. M. Bohre, Paul F. J. Houben and Shoshan Knaan-Shanzer
- Book ID
- 123637432
- Publisher
- National Academy of Sciences
- Year
- 1989
- Tongue
- English
- Weight
- 1019 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/34804
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๐ SIMILAR VOLUMES
## Objective. To investigate the role of bone marrow in arthritis. Methods. Bone marrow changes over time were investigated in rats with adjuvant-induced and collageninduced arthritis, using bioassay techniques and histologic analysis. Results. In both animal models, bone marrow interleukin-1 and
Adult Lewis rats were thymectomized, irradiated (900 r), and given bone marrow cells from normal (BN X Lewis) F, donors. Passive transfer of adjuvant arthritis was carried out with lymph node cells of Lewis donors sensitized 9 days earlier. The recipients showed clinical arthritis starting at 3-8 da