Bone marrow as source of cells in reactions of cellular hypersensitivity. III. Adjuvant arthritis in the rat
✍ Scribed by Deborah A. Putnam; David M. Lubaroff; Byron H. Waksman
- Publisher
- John Wiley and Sons
- Year
- 1969
- Tongue
- English
- Weight
- 330 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0004-3591
No coin nor oath required. For personal study only.
✦ Synopsis
Adult Lewis rats were thymectomized, irradiated (900 r), and given bone marrow cells from normal (BN X Lewis) F, donors. Passive transfer of adjuvant arthritis was carried out with lymph node cells of Lewis donors sensitized 9 days earlier. The recipients showed clinical arthritis starting at 3-8 days and were sacrificed at 9-13 days. Live cell
T into rats induces in approximately 10 days a symmetrical polyarthritis with associated iridocyclitis, subcutaneous nodules, and mucocutaneous lesions which increase in severity for about 2 weeks. Evidence has been presented that this disease is a delayed hypersensitivity response to a disseminated antigen, the exact nature of which is not known but is thought to be a constituent of the injected tubercle baci1li.l The disease cannot be transferred by serum but can be transferred by living sensitized lymphoid cells to recipient rats of the same inbred strain.*s3
The early arthritis lesions are sites of extensive mononuclear cell infiltration4 with later lesions showing also an increased fibroblastic response in and about the joints.6 The majority of infiltrating mononuclear