Bone Marrow Changes in Adjuvant-Induced and Collagen-Induced Arthritis

✍ Scribed by Kenji Hayashida; Takahiro Ochi; Masahiro Fujimoto; Hajime Owaki; Yasunori Shimaoka; Kero Ono; Keishi Matsumoto

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 526 KB
• Volume: 35
• Category: Article
• ISSN: 0004-3591
• DOI: 10.1002/art.1780350219

✦ Synopsis

Objective. To investigate the role of bone marrow in arthritis.

Methods. Bone marrow changes over time were investigated in rats with adjuvant-induced and collageninduced arthritis, using bioassay techniques and histologic analysis.

Results. In both animal models, bone marrow interleukin-1 and interleukin-6 activity began to rise before the onset of arthritis and increased in relation to the progression of arthritis. Enhanced myelopoiesis in the bone marrow was noted in conjunction with the increased cytokine activity.

Conclusion.

Bone marrow changes such as those demonstrated in this study may be common to various models of induced arthritis and may have an important role in the pathogenesis of this disease.

In rheumatoid arthritis (RA), the main pathologic process is usually thought to be inflammation of the synovium. Most investigators have therefore focused on this tissue in studies attempting to elucidate From the