Regioselective ring opening of steroidal epoxide with hydrides: Formation of C(2)- and C(3)-Deoxyasiatic acid derivatives
โ Scribed by Sang-sup Jew; Dooyeon Lim; Sung Ki Seo; Tae Gyu Nam; Hyeung-geun Park; Hee-Doo Kim; Chang Min Kim; Min Hee Lee; Hyeung Geun Paik; Min Jung Lee; Young Hoon Jung
- Book ID
- 105672701
- Publisher
- Springer
- Year
- 1998
- Tongue
- English
- Weight
- 206 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0253-6269
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๐ SIMILAR VOLUMES
Yttrium nitrate hexahydrate [Y(NO 3 ) 3 ร6H 2 O] was found to be an efficient catalyst for selective ring opening of epoxides with aliphatic, aromatic, and heteroaromatic amines at room temperature under solvent-free conditions. The system tolerated a variety of hindered and functionalized epoxides/
## Abstract The title compounds 7 were prepared in situ by deprotection of the corresponding pivaloylโsubstituted oxetanes 3 with lithium aluminium hydride in tetrahydrofuran. under these conditions a reductive ring opening at cโ2 (hydrodealkoxylation) occurred which was initiated by a nucleophilic