Regioselective O-acylation of myo-inositol 1,3,5-orthoesters: the role of acyl migration

✍ Scribed by K.M Sureshan; M.S Shashidhar

• Book ID: 104210328
• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 95 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)00561-x

✦ Synopsis

An efficient and general method for the preparation of 2-O-acylated derivatives of myo-inositol 1,3,5-orthoesters via isomerization of the corresponding 4(6)-O-acylated derivatives has been described. The isomerization involves a novel 1(axial)→3(equatorial) intramolecular acyl migration assisted by a metal ion.