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Synthesis of 1-O-alkyl- and 1-O-acyl-myo-inositol 3, 4, 5-trisphosphates as novel analogues of phosphatidyl-myo-inositol 3, 4, 5-trisphosphate

✍ Scribed by Takayuki Sawada; Ryuichi Shirai; Yuji Matsuo; Yukihito Kabuyama; Koutarou Kimura; Yasuhisa Fukui; Yuichi Hashimoto; Shigeo Iwasaki


Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
200 KB
Volume
5
Category
Article
ISSN
0960-894X

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Novel routes to myo-inositol 1,4,5trisphosphate and a phosphorothioate analogue involving mixed P(V) and P(III) chemistry have been developed. Phosphorylation of 2,3,6-tri-O-benzyl-myo-inositol l-[di-(2,2,2-trichloroethyl) phosphate] with bis(2,2,2-trichloroethyl) phosphorochloridate gave a mixture