Synthesis of 1-O-alkyl- and 1-O-acyl-myo-inositol 3, 4, 5-trisphosphates as novel analogues of phosphatidyl-myo-inositol 3, 4, 5-trisphosphate
β Scribed by Takayuki Sawada; Ryuichi Shirai; Yuji Matsuo; Yukihito Kabuyama; Koutarou Kimura; Yasuhisa Fukui; Yuichi Hashimoto; Shigeo Iwasaki
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 200 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0960-894X
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myo-Inositol 1,4,6-u-&phosphate, in optically inactive and active forms, was prepared in order to compare its biological activity with that of myo-inositol 1,3,4,6-tetrakisphosphate which releases Ca2+ from an intracellular store.
Novel routes to myo-inositol 1,4,5trisphosphate and a phosphorothioate analogue involving mixed P(V) and P(III) chemistry have been developed. Phosphorylation of 2,3,6-tri-O-benzyl-myo-inositol l-[di-(2,2,2-trichloroethyl) phosphate] with bis(2,2,2-trichloroethyl) phosphorochloridate gave a mixture