he following proportions of cancers are unresectable at the time T of diagnosis: colorectal, 30%; pancreas, 85%; gastric, 60%; and ovarian, 75%. These advanced cancers will most likely involve the entire peritoneal cavity. However, at autopsy, 25-50% are still confined to the abdominal cavity. The s
Regional perfusion with hemofiltration (chemofiltration) for the treatment of patients with regionally advanced cancer
โ Scribed by Mordechai Gutman; Subhi Abu-Abid; Patrick Sorkine; Moshe Inbar; Dina Lev; Zipora Chen; Dan Oron; Samario Chaitchik; Joseph M. Klausner
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 520 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
No coin nor oath required. For personal study only.
โฆ Synopsis
BACKGROUND.
Regionally advanced cancer is a common, often unresolved problem. Effective local control with chemotherapy is limited by the toxicity following systemic administration. Chemofiltration (CF) is a form of regional perfusion that enables the administration of cytotoxic drugs into one body area while limiting systemic toxicity. The drug is infused into the artery supplying the involved area. The venous effluent of the same organ is pumped out into a hemofiltration unit at a high flow rate. The drug is then filtered away and the blood returned to systemic circulation.
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From 1978 to 1990, 32 patients with Clark V melanoma were treated by wide excision of the primary and adjuvant regional isolated perfusion with melphalan. M.D. Anderson stage of disease was stage I in 22 and stage IIIb in 10 patients. Five-year survival rates were 58% and 27%, respectively. Seven pa
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