Regional chemotherapy plus hemofiltration for the treatment of regionally advanced malignancy

✍ Scribed by James H. Muchmore

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 233 KB
• Volume: 78
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19960901)78:5<941::aid-cncr1>3.0.co;2-f

✦ Synopsis

he following proportions of cancers are unresectable at the time T of diagnosis: colorectal, 30%; pancreas, 85%; gastric, 60%; and ovarian, 75%. These advanced cancers will most likely involve the entire peritoneal cavity. However, at autopsy, 25-50% are still confined to the abdominal cavity. The study by Gutman et al. in this issue of Cancer nicely addresses some of the feasibility and treatment issues of locally advanced cancers within the abdominal cavity.'

Patients with advanced intraabdominal cancer, whether treated by surgery alone or in combination with systemic chemoradiotherapy, receives marginal benefit from the therapy. Aggressive surgical attempts at eradication may help only a small subset of patients.' Early local recurrence and dissemination are the usual result without affecting the survival. Most evident is the case of the supraradical resection for pancreas adenocarcinoma. Furthermore, the Achilles' heels in treating advanced intraabdominal malignancies are the peritoneal surfaces. These