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Adjuvant regional isolated perfusion with melphalan for patients with clark V melanoma of the extremities

✍ Scribed by Bart C. Vrouenraets; Dr. Bin B. R. Kroon; Joost M. Klaase; Bert N. Van Gell; Alexander M. M. Eggermont; Hilary R. Franklin

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
419 KB
Volume
52
Category
Article
ISSN
0022-4790

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✦ Synopsis

From 1978 to 1990, 32 patients with Clark V melanoma were treated by wide excision of the primary and adjuvant regional isolated perfusion with melphalan. M.D. Anderson stage of disease was stage I in 22 and stage IIIb in 10 patients. Five-year survival rates were 58% and 27%, respectively. Seven patients developed a recurrence in the perfused limb [stage I, 2, stage IIIb, 5 patients ( P = 0.03)], and 4 of 17 patients developed regional lymph node metastases. Of the well-known prognostic variables, only ulceration of the primary tumor significantly influenced survival ( P = 0.03). We did not see any improvement in survival rates compared with literature data on nonperfused patients. In the absence of data on locoregional recurrence rates in nonperfused Clark V melanoma patients, we cannot say whether adjuvant perfusion diminished this risk. Therefore, the results of the prospective randomized EORTCiWHO trial in primary high-risk extremity melanoma have to be awaited. 0 1993 Wiley-Liss, h c .

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