Regional loss of chromosome 10 in glioblastoma multiforme (GBM)
โ Scribed by A. Rasheed; X. He; D.D. Bigner; S.H. Bigner
- Book ID
- 119105107
- Publisher
- Elsevier Science
- Year
- 1991
- Tongue
- English
- Weight
- 56 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0165-4608
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Cytogenetic and restriction fragment length polymorphism (RFLP) studies have shown that loss of one entire copy of chromosome 10 is a common genetic event in glioblastoma multiforme, the most malignant glial brain tumor in humans. In a search for submicroscopic deletions, we carried out
Gene deletion of chromosome 10 in 11 tumor tissues removed from nine patients with malignant glioma (seven glioblastomas and two malignant astrocytomas) was investigated. Loss of heterozygosity was found in four of the seven (57%) cases with glioblastoma, whereas heterozygosity was preserved in two
## Abstract Glioblastoma multiforme (GM) is the most lethal form of brain tumor, with a median survival of approximately 1 year. Treatment options are limited. Radiation therapy is a common form of treatment, but many tumors are resistant. In earlier studies, we found that gain of chromosome 7 is a