Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme
✍ Scribed by Anjan Misra; Malgorzata Pellarin; Lily Hu; Sandeep Kunwar; Mark Perhouse; Kathleen R. Lamborn; Dennis F. Deen; Burt G. Feuerstein
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 657 KB
- Volume
- 45
- Category
- Article
- ISSN
- 1045-2257
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✦ Synopsis
Abstract
Glioblastoma multiforme (GM) is the most lethal form of brain tumor, with a median survival of approximately 1 year. Treatment options are limited. Radiation therapy is a common form of treatment, but many tumors are resistant. In earlier studies, we found that gain of chromosome 7 is associated with radiation resistance in human primary GM. In this study, we extend that result to a model system in which we transferred chromosome 7 to recipient cells and confirmed radiation resistance as a function of chromosome 7 gain. We identified three candidate regions on chromosome 7 that conferred radiation resistance in our model system. © 2005 Wiley‐Liss, Inc.