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Regional localization of two non-specific X-linked mental retardation genes (MRX30 andMRX31)

✍ Scribed by Donnelly, Andrew J.; Partington, Michael W.; Ryan, Anna K.; Mulley, John C.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 124 KB
Volume: 64
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960712)64:1<113::aid-ajmg19>3.0.co;2-q

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✦ Synopsis

Two genes responsible for X-linked mental retardation have been localised by linkage analysis. MRX30 maps to a 28 cM region flanked by the loci DXS990 (Xq21.3) and DXS424 (Xq24). A significant multipoint lod score of 2.78 was detected between the loci DXSll20 and DXS456. MRX31 maps to a 12 cM region that spans the centromere from DXS1126 (Xp11.23) to DXS1124 (Xq13.3). Significant two-point lod scores, at a recombination fraction of zero, were obtained with the loci DXS991 (Zmax = 2.06), AR (Zmax = 3.44), PGKlPl (Zmax = 2.06) and DXS453 (Zmax = 3.31). The MRX30 localisation overlaps that of MRX8,13,20 and 26 and defines the position of a new MRX gene on the basis of a set of non-overlapping regional localisations. The MRX31 localisation overlaps the localisations of many of the pericentromeric MRX loci (

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