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Regional chromosomal localization of the human gene for galactose-1-phosphate uridyltransferase

✍ Scribed by N. C. Sun; C. R. Y. Sun; E. H. Y. Chu

Publisher: Springer
Year: 1977
Tongue: English
Weight: 376 KB
Volume: 37
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00393609

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✦ Synopsis

In the progeny of somatic cell hybrids formed by fusion of human lymphocytes and Chinese hamster mutant cells, a single human chromosome A2 was selectively retained when grown in appropriate medium. Spontaneous breakage of this chromosome in different hybrid subclones led to the assignment of the gene for galactose-1-phosphate uridyltransferase to the centromeric region of this chromosome (2q11 leads to 2q14). This gene is shown to be syntenic to the previously mapped genes for acid phosphatase 1 and malate dehydrogenase 1.

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