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Regiocontrolled metalation of diethyl β-dialkylaminovinylphosphonates: A new synthesis of substituted β-ketophosphonates

✍ Scribed by Robert K. Boeckman Jr.; Michael A. Walters; Hiroshi Koyano


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
265 KB
Volume
30
Category
Article
ISSN
0040-4039

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✍ Nicolas Auberger; Christine Gravier-Pelletier; Yves Le Merrer 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB

## Abstract A concise route to a new β‐ketophosphonate analog of glycosyl nucleotides is described. Such a diphosphate bioisostere is a stable mimic of enzyme substrates involved in peptidoglycan biosynthesis and will be the starting point for the development of new potential antibiotics. The synth