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Regio- and stereoselective synthesis of the major metabolite of quercetin, quercetin-3-O-β-d-glucuronide

✍ Scribed by Mohamed Bouktaib; Aziz Atmani; Christian Rolando

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
130 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Protected quercetin was first transformed selectively in its 3-O-b-D-glucoside. Further protection of the remaining phenolic hydroxyl group allows a clean oxidation of the glucoside by TEMPO/NaOCl/NaBr under phase transfer conditions into the corresponding glucuronide which was cleanly deprotected to quercetin-3-O-b-D-glucuronide.

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