Regeneration of ischemic heart using hyaluronic acid-based injectable hydrogel

✍ Scribed by So Jeong Yoon; Yong Hu Fang; Choon Hak Lim; Bum Shik Kim; Ho Sung Son; Yongdoo Park; Kyung Sun

• Book ID: 102874057
• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 502 KB
• Volume: 91B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31386

✦ Synopsis

Abstract

An injectable hydrogel was applied to regenerate a myocardial infarction and functional recovery of the heart. A myocardial infarction was induced in rat by circumflex artery ligation. A hyaluronic acid‐based hydrogel was injected into the epicardium of the infarcted area. Then, cardiac functions and regeneration of the myocardium in sham‐operated (SHAM), myocardial infarction (MI), and gel‐injected group (GEL) (n = 6) were evaluated 4 weeks after the injection. Measurements of the thickness of the wall showed that the thickness in the GEL group increased by up to 200% compared with that in the MI group (p < 0.001). The infarcted area of the left ventricular in the GEL group decreased by 53% compared with the MI group (p < 0.001). The number of arterioles and capillaries in the border zone of the GEL group increased by 152% and 148%, whereas the apoptotic index decreased by 42% (p < 0.05). Measurement of the heart functions, such as ejection fraction, arterial elastance (Ea), d__P__/d__t__ max, and d__P__/d__t__ min, indicated that the injection of a hydrogel significantly facilitated the functional recovery compared with the MI group. Because of its simplicity, easy applicability, and a great regenerating potential, this injectable hydrogel promises as a treatment for myocardial infarction. © 2009 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2009