Injectable hydrogels based on hyaluronic acid (HA) and poly(ethylene glycol) (PEG) were designed as biodegradable matrices for cartilage tissue engineering. Solutions of HA conjugates containing thiol functional groups (HA-SH) and PEG vinylsulfone (PEG-VS) macromers were cross-linked via Michael add
โฆ LIBER โฆ
Rapid gelation of injectable hydrogels based on hyaluronic acid and poly(ethylene glycol) via Michael-type addition
โ Scribed by Rong Jin; Pieter J. Dijkstra; Jan Feijen
- Book ID
- 113693432
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 248 KB
- Volume
- 148
- Category
- Article
- ISSN
- 0168-3659
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## Abstract An acryloyl end-capped four-arm star-shaped poly(ethylene glycol)-branched-oligo(l-lactide) (4A-PEG-PLA) macromer was firstly prepared. A novel kind of hydrogels was synthesized via the Michael-type addition reaction between (2S,3S)-1,4-bis-sulfanylbutane-2,3-diol (dithiothreitol) and t