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Refinement of the rat crush-avulsion femoral artery injury model

✍ Scribed by Dr. Michael D. Rooks; Jorge Rodriquez; Mark McNaughton; Kip Turnidge; Kathy Zusmanis; William Hutton

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
474 KB
Volume
14
Category
Article
ISSN
0738-1085

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✦ Synopsis

Abstract

A model for studying arterial crush‐avulsion injuries in the rat is described. The model uses a standardized crush of ∼0.3 joules and a standardized avulsion. The crush is accomplished by gravity acceleration of a 400 g weight over a distance of 7.5 cm. The weight impacts an anvil over the artery distributing the force of the impact over a 10 mm length of the vessel. The avulsion is accomplished by a hemostat attached to a second, 120g weight. Vascular stasis for 90 sec after vessel repair in a 175–225 g rat will consistently result in an 80% anastomotic failure. The model allows evaluation of anticoagulant effects singly or in combination. Agents may be given either systemically by intravenous route or locally by intraarterial route. Β© 1993 Wiley‐Liss Inc.

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