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Microvascular repair following a modified crush-avulsion injury in a rat model: Effect of recombinant human tissue-type plasminogen activator on the patency rate

✍ Scribed by Efstathios G. Lykoudis; Petros N. Panayotou; Constantinos N. Stamatopoulos; Konstantina B. Frangia; Apostolos E. Papalois; John D. Ioannovich

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
579 KB
Volume
20
Category
Article
ISSN
0738-1085

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✦ Synopsis

The failure rate of replantations following a crush-avulsion type injury is high. This study has been designed to reproduce an effective standardized crush-avulsion injury model to the femoral artery of the rat and evaluate the antithrombotic efficacy of systemic intravenous administration of recombinant human tissue-type plasminogen activator (rt-PA). The crush-avulsion injury was reproduced by using a bulldog clamp and two hemostats and followed by microvascular repair. The animals were divided into three groups of 20 rats each and received either normal saline, heparin 100 U/kg body weight, or rt-PA 3.5 mg/kg body weight intravenously. Patency tests were performed 20 min and 48 h after blood flow reestablishment. Results showed that this experimental crush-avulsion injury model ensures low patency in the control group, whereas systemic rt-PA administration improves the patency rate statistically significantly compared to control and heparin groups at both 20 min and 48 h postrevascularization.

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