Reductive formylation of N,N-dimethyl-p-nitrosoaniline by glyoxylic acid. Evidence for a hydroxamic acid intermediate
β Scribed by Corbett, Michael D.; Corbett, Bernadette R.
- Book ID
- 121364452
- Publisher
- American Chemical Society
- Year
- 1981
- Tongue
- English
- Weight
- 443 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-3263
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Peroxynitrite (ONOO-) has been found to react with the title amine 1 and quinone 5 to form N-nitrosoamine 2 and 2,3-epoxide 6, respectively, in accord with the in situ generation of the nitrosonium and hydroperoxide ions as the respective reactive species.
An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogr