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An efficient synthesis of a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 via asymmetric dianionic cyanomethylation of N-Boc-l-(+)-glutamic acid dimethyl ester

✍ Scribed by Qingping Tian; Naresh K Nayyar; Srinivasan Babu; Lijian Chen; Junhua Tao; Steven Lee; Anthony Tibbetts; Terence Moran; Jason Liou; Ming Guo; Timothy P Kennedy

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 65 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01416-2

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✦ Synopsis

An efficient synthetic route to a key intermediate for the preparation of the rhinovirus protease inhibitor AG7088 has been developed employing a key asymmetric dianionic cyanomethylation of N-Boc-L-(+)-glutamic acid dimethyl ester. This methodology enables the preparation of this compound in kilogram quantities with an overall yield of 30%.

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ChemInform Abstract: An Efficient Synthe

ChemInform Abstract: An Efficient Synthesis of a Key Intermediate for the Preparation of the Rhinovirus Protease Inhibitor AG7088 via Asymmetric Dianionic Cyanomethylation of N-Boc-L-(+)-glutamic Acid Dimethyl Ester.

✍ Qingping Tian; Naresh K. Nayyar; et al. et al. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 31 KB 👁 2 views

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