Reductive Debromination of 1,2-Bis(bromomethyl)arenes Using Tetrakis(dimethylamino)ethylene (TDAE).
β Scribed by Yutaka Nishiyama; Hiroshi Kawabata; Akihiro Kobayashi; Toshiki Nishino; Noboru Sonoda
- Book ID
- 101976594
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 23 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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π SIMILAR VOLUMES
Tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant of chlorodifluoromethylated ketones 1-3. The generated ~,~-difluoroacetyl anion was trapped with several aldehydes 4-7, under mild conditions, to give the corresponding 2,2-difiuoro-3-hydroxy ketone derivatives 8-13, in mo
Tetrakis(dimethylamino)ethylene (TDAE) as a Useful Reductant of Some Chlorodifluoromethylated Ketones. A New Approach for the Synthesis of Ξ±,Ξ±-Difluoroketone Derivatives. -Reduction of chlorodifluoromethylated ketones with TDAE as an effective reductant generates Ξ±,Ξ±-difluoroacetyl anions, which ar