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Reductive conversion of N-terminal pyroglutamyl into prolyl residues in polypeptides and proteins

โœ Scribed by Takahashi, Sho; Cohen, Louis Arthur


Book ID
126325199
Publisher
American Chemical Society
Year
1969
Tongue
English
Weight
668 KB
Volume
8
Category
Article
ISSN
0006-2960

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Determination of the N-Terminal residue
โœ Constance M. Harris; Thomas M. Harris ๐Ÿ“‚ Article ๐Ÿ“… 1979 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 243 KB

The N-terminus of ristocetin A and ristomycin A was found to be the p-hydroxyphenylglycine ring of ristomycinic acid by reductive alkylation of the peptide with acetone and NaCNBH3 followed by peptide hydrolysis and separation of the two rings of the isopropyl amino acid by hydrogenolysis. Ristocet