Reductive alkylation of monoaromatic ketones
β Scribed by Narisada, Masayuki; Watanabe, Fumihiko
- Book ID
- 126160235
- Publisher
- American Chemical Society
- Year
- 1973
- Tongue
- English
- Weight
- 875 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
SmI2-HMPA was shown to be an effective reagent for reductive alkylation of 0t-cyano ketones, a useful process for regiocontrol of et,et-dialkylation of ketones.
3-Alkylindoles were prepared in one step from indoles and ketones via a convenient reductive alkylation procedure using triethylsilane and trichloroacetic acid. Under this particular condition, unsubstituted indoles could be tolerated to afford good yields of 3-sec-alkylation products.
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