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Reduction of protriptyline-photosensitized hemolysis by β-cyclodextrin complexations

✍ Scribed by Hoshino, Teruhiko; Hirayama, Fumitoshi; Uekama, Kaneto; Yamasaki, Masaki

Book ID
122397319
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
602 KB
Volume
50
Category
Article
ISSN
0378-5173

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✍ Nao Ono; Yuji Miyamoto; Takako Ishiguro; Keiichi Motoyama; Fumitoshi Hirayama; D 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 546 KB

Reduction of bitterness of antihistaminic drugs by cyclodextrin (CyD) complexation was examined. The stability constant (Kc) of the 1:1 CyD inclusion complexes with antihistaminic drugs increased in the order of 2-hydroxypropyl-β-CyD (HP-β-CyD) ≈ β-CyD > γ-CyD > α-CyD for diphenhydramine and epinast