Reduction of indolo[2,3-a]quinolizidines with baker's yeast
✍ Scribed by F. A. Farés; H. Virelizier; K. Jankowski; G. W. Gribble
- Book ID
- 112131340
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1995
- Tongue
- English
- Weight
- 170 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0022-152X
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Using fermenting baker's yeast, Z-RCH=CClCOCH3 (R=C2HS, n-C5Hll, n-CaH17) was reduced initially to (S)-RCH2EHClCOCH3 in 44-84% ee, which was further reduced to RCH2?HCltHOHCH3 in >98% ee with the syn(2S,3S)/anti(2S,3R) ratios of 2.6-18.3. The use of fermenting baker's yeast has been shown to provid
## Abstract Bioreduction of 3‐substituted‐2‐oxoal‐kanephosphonates by baker's yeast afforded 3‐substituted‐2‐hydroxy‐alkanephosphonates in moderate to good yields and ee value. These compounds could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of biologically acti