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Synthesis of Indolo[2,3- a ]quinolizidine-3-One

✍ Scribed by Manna, Ranjan K.; Jaisankar, Parasuraman; Giri, Venkatachalam S.


Book ID
120881331
Publisher
Taylor and Francis Group
Year
1995
Tongue
English
Weight
276 KB
Volume
25
Category
Article
ISSN
0039-7911

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12b-Substituted indolol2,3-a]quinolizidin-2-ones 5 are synthesized by treatment of Grignard reagents with O-acetyl iminium salt 4 generated by treating cyclic enaminoketone 3 with acetyl chloride. Subsequent Robinson annulation employing the Stork enamine protocol provided rac-3-phenyl-15,16dehydror