Installation of 12b-substituents onto in
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Jie Jack Li; Bharat.K. Trivedi; J.Ronald Rubin; Bruce D. Roth
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Article
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1998
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Elsevier Science
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French
β 225 KB
12b-Substituted indolol2,3-a]quinolizidin-2-ones 5 are synthesized by treatment of Grignard reagents with O-acetyl iminium salt 4 generated by treating cyclic enaminoketone 3 with acetyl chloride. Subsequent Robinson annulation employing the Stork enamine protocol provided rac-3-phenyl-15,16dehydror