𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Reduction of first-pass hepatic clearance of propranolol by food

✍ Scribed by McLean, Allan J; Isbister, Cheryl; Bobik, Alex; Dudley, Francis J

Book ID
109843033
Publisher
Nature Publishing Group
Year
1981
Tongue
English
Weight
240 KB
Volume
30
Category
Article
ISSN
0009-9236

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

A computer simulation of the food effect
A computer simulation of the food effect: Transient changes in hepatic blood flow and michaelis-menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol
✍ H. A. Semple; Dr. Y. K. Tam; R. T. Coutts πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 744 KB

A physiological model of propranolol disposition was designed to help explain the large increase in AUC seen when the drug is administered with food. The mass balance equation for the liver compartment used Michaelis-Menten terms to describe hepatic metabolism. Previously published pharmacokinetic a