𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A METHOD OF DETERMINING INTRINSIC HEPATIC CLEARANCE FROM THE FIRST-PASS EFFECT

✍ Scribed by L. Bass; K. Winkler

Book ID
108932924
Publisher
John Wiley and Sons
Year
1980
Tongue
English
Weight
287 KB
Volume
7
Category
Article
ISSN
0305-1870

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A computer simulation of the food effect
A computer simulation of the food effect: Transient changes in hepatic blood flow and michaelis-menten parameters as mediators of hepatic first pass metabolism and bioavailability of propranolol
✍ H. A. Semple; Dr. Y. K. Tam; R. T. Coutts πŸ“‚ Article πŸ“… 1990 πŸ› John Wiley and Sons 🌐 English βš– 744 KB

A physiological model of propranolol disposition was designed to help explain the large increase in AUC seen when the drug is administered with food. The mass balance equation for the liver compartment used Michaelis-Menten terms to describe hepatic metabolism. Previously published pharmacokinetic a