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Reduction of fibronectin expression by intravitreal administration of antisense oligonucleotides

✍ Scribed by Roy, Sayon; Zhang, Kathy; Roth, Timothy; Vinogradov, Sergei; Kao, Richard S.; Kabanov, Alexander


Book ID
109830251
Publisher
Nature Publishing Group
Year
1999
Tongue
English
Weight
199 KB
Volume
17
Category
Article
ISSN
1087-0156

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In this study, we investigated the role of acyl-coenzyme A:diacylglycerol acyltransferase 2 (DGAT2) in glucose and lipid metabolism in obese mice by reducing its expression in liver and fat with an optimized antisense oligonucleotide (ASO). High-fat diet-induced obese (DIO) C57BL/6J mice and ob/ob m