Proliferative effect of high glucose is modulated by antisense oligonucleotides against fibronectin in rat endothelial cells

Increased endocytosis in retinal vascula

Increased endocytosis in retinal vascular endothelial cells grown in high glucose medium is modulated by inhibitors of nonenzymatic glycosylation

✍ A. W. Stitt; U. Chakravarthy; D. B. Archer; T. A. Gardiner 📂 Article 📅 1995 🏛 Springer 🌐 English ⚖ 878 KB

We sought to determine if hyperglycaemia is responsible for increased retinal vascular endothelial-cell (RVEC) endocytosis in diabetes and to assess the role of nonenzymatic glycosylation in mediation of this novel endothelial-cell pathology. RVECs were propagated in media containing either 5 or 25