Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

Reduction of liver tumor necrosis factor

Reduction of liver tumor necrosis factor-α expression by targeting delivery of antisense oligonucleotides into Kupffer cells protects rats from fulminant hepatitis

✍ Lei Dong; Longsheng Zuo; Suhua Xia; Shuying Gao; Chenyu Zhang; Jiangning Chen; J 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 639 KB

## Abstract ## Background Fulminant liver failure can cause extreme mortality due to the lack of effective and targeting therapeutics for the disease. Novel therapeutics using antisense technology require an efficient and safe delivery system with Kupffer cell targeting ability. ## Methods We ex