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Reduction of estrogen and prolactin receptors in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumor by high doses of estrogen

✍ Scribed by Nobuyuki Shigaki; Masaharu Kimura; Sadamu Takano; Noboru Fujino; Masanobu Akagi


Book ID
112755656
Publisher
Springer
Year
1987
Tongue
English
Weight
493 KB
Volume
17
Category
Article
ISSN
1436-2813

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The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10