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Effects of estradiol and prolactin on steroid receptor levels in 7,12-dimethylbenz(a)anthracene-induced mammary tumors and uterus in the rat

✍ Scribed by Jacques Asselin; Fernand Labrie

Book ID
116000869
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
407 KB
Volume
9
Category
Article
ISSN
0022-4731

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On the mechanism of hormone action in 7,
On the mechanism of hormone action in 7, 12 dimethylbenz(A) anthracene-induced mammary tumor. I. Prolactin and progesterone effects on estrogen receptor in vitro
✍ Gordon H. Sasaki; Dr. Benjamin S. Leung πŸ“‚ Article πŸ“… 1975 πŸ› John Wiley and Sons 🌐 English βš– 552 KB

The presence of ER in DMBA-tumors was demonstrated by the use of dextrancharcoal assay, sephadex chromatography, sucrose gradient sedimentation, and organ culture techniques. It was found that tumors have binding sites ranging from 10-" to 10-l' moles/mg protein, and a dissociation constant of ER 10