Reduction of Azide to Amine Using Fe/AlCl3 or Fe/BiCl3 System in Aqueous EtOH

✍ Scribed by Peng-Wu Zheng; Xue-Min Xie; Wei Wang; Xiao-Ji Wang; Yu-Ping Guo; Qi-Dong Tu

• Book ID: 102098951
• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 26 KB
• Volume: 24
• Category: Article
• ISSN: 0256-7660
• DOI: 10.1002/cjoc.200690157

✦ Synopsis

Abstract

Azides were reduced to the corresponding amines by two new metal/Lewis acid systems in aqueous EtOH with yields ranging from 80% to 95%. The new reduction systems were Fe/AlCl~3~·6H~2~O or Fe/BiCl~3~ system in H~2~O/ethanol (2:1, V:V) at room temperature. Fifteen azides with different functional groups were well reduced to the corresponding amines in excellent yields.