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Reduced water exchange in sickle cell anemia red cells: a membrane abnormality

✍ Scribed by L.W.-M. Fung; C. Narasimhan; H.-Z. Lu; M.P. Westerman


Book ID
115728896
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
403 KB
Volume
982
Category
Article
ISSN
0005-2736

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## Abstract Chronic simple hypertransfusion (every 3 to 4 weeks) effectively prevents secondary stroke in children with sickle cell anemia but leads to iron overload despite chelation therapy. Conventional red blood cell exchange (C‐RBCx) has advantages over simple transfusion: no net iron gain and