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Reduced expression of cell-cycle regulator p27Kip1 correlates with a shortened survival in non-small cell lung cancer

✍ Scribed by Tsukamoto, Shuichi; Sugio, Kenji; Sakada, Takashi; Ushijima, Chie; Yamazaki, Koji; Sugimachi, Keizo


Book ID
118570531
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
304 KB
Volume
34
Category
Article
ISSN
0169-5002

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Human lung cancer cells, including small cell lung carcinoma (SCLC), frequently lose expression of retinoic acid receptor ␀ (RAR-␀) and are resistant to the growth inhibitory activity of all-trans retinoic acid (RA). To elucidate the role of RAR-␀ in the growth regulation of SCLC by retinoids, we re