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Protein Expression of Cell Cycle Regulator, p27Kip1, Correlates with Histopathological Grade of Non-Hodgkin's Lymphoma

✍ Scribed by Kudoh, Shiori ;Kumaravel, Tirukalikundram S. ;Kuramavel, Bharathy ;Eguchi, Minenori ;Asaoku, Hideki ;Dohy, Hiroo ;Fujiwara, Megumi ;Sasaki, Naomi ;Tanaka, Kimio ;Kamada, Nanao

Book ID: 108581703
Publisher: Wiley (Blackwell Publishing)
Year: 1999
Tongue: English
Weight: 273 KB
Volume: 90
Category: Article
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1999.tb00706.x

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## Abstract ## BACKGROUND Low levels of p27^Kip1^ are associated with high aggressiveness and poor prognosis in various malignancies, including colorectal carcinoma. The authors showed that S phase kinase protein 2 (Skp2), the specific ubiquitin ligase subunit that targets p27^Kip1^ for degradatio