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Reduced (±)-3,4-methylenedioxymethamphetamine (“Ecstasy”) metabolism with cytochrome P450 2D6 inhibitors and pharmacogenetic variants in vitro

✍ Scribed by Yamini Ramamoorthy; Ai-ming Yu; Nina Suh; Robert L Haining; Rachel F Tyndale; Edward M Sellers

Book ID
113993080
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
164 KB
Volume
63
Category
Article
ISSN
0006-2952

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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab