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Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.

✍ Scribed by Z Liu; O Mortimer; CA Smith; CR Wolf; A Rane


Book ID
117945672
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
485 KB
Volume
39
Category
Article
ISSN
0306-5251

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Metabolism of Dextromethorphan in vitro:
✍ JÜRGEN SCHMIDER; DAVID J. GREENBLATT; STEVEN M. FOGELMAN; LISA L. VON MOLTKE; RI πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 191 KB πŸ‘ 1 views

Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab