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Role of rat liver cytochrome P450 3A and 2D in metabolism of imrecoxib

✍ Scribed by Hai-yan XU; Zhi-yong XIE; Peng ZHANG; Jin SUN; Feng-ming CHU; Zong-ru GUO; Da-fang ZHONG

Book ID
111354989
Publisher
Nature Publishing Group
Year
2006
Tongue
Chinese
Weight
672 KB
Volume
27
Category
Article
ISSN
1671-4083

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The metabolism and covalent binding of 14 C-monocrotaline in Sprague-Dawley (SD) rat liver microsomes was investigated using the inducers dexamethasone, clotrimazole, pregnenolone-16␣-carbonitrile, and phenobarbital. Monocrotaline is a pyrrolizidine alkaloid (PA) that causes a syndrome in rats that