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Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4

✍ Scribed by J. Fang; Michel Bourin; Glen B. Baker


Publisher
Springer-Verlag
Year
1999
Tongue
English
Weight
81 KB
Volume
359
Category
Article
ISSN
0028-1298

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Dextromethorphan (DMO), a cough suppressing synthetic analog of codeine, undergoes parallel O-demethylation to dextrorphan (DOP), and N-demethylation to 3-methoxymorphinan (MEM), in humans. 3-hydroxymorphinan, a didemethylated metabolite, is formed secondarily. O-demethylation activity is well estab